AstraZeneca Posted August 11, 2026

Director, Bacterial Vaccine Discovery

Gaithersburg, Maryland, United States of America Full time
Drug Discovery & Preclinical Research Vaccines & Infectious Disease Director

AstraZeneca is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.

About this opportunity

The Director of Bacterial Vaccine Discovery in Early Infectious Disease leads efforts to discover and develop bacterial vaccines, including carbohydrate conjugate, mRNA, and protein-based approaches. The individual will lead a team of scientists in discovering and characterizing novel bacterial vaccines to build and advance the portfolio. The team will collaborate across groups within Bacterial Vaccines to identify effective vaccine candidates and fully characterize their immunogenicity and efficacy in preclinical disease models. The role also requires influencing senior internal stakeholders in Research, Bioprocess Development, and Regulatory Affairs, as well as managing external academic collaborations and contract research organizations to deliver the early vaccine portfolio.

Accountabilities

Lead a team of scientists to discover and characterize candidate vaccine antigens, delivering robust in vitro and in vivo research packages that support pipeline progression and regulatory interactions.

Serve as subject matter expert and research lead for multiple programs, presenting strategy and data to senior leaders at governance meetings.

Present key findings and research progress at top-tier scientific conferences.

Partner with Early Vaccines and Immune Therapies Translational Sciences to develop and transfer assays for characterizing immune responses in future clinical trials.

Oversee and maintain accountability for partnerships with third parties, including academic institutions and biotech collaborators.

Evaluate external science and partnering opportunities in collaboration with Business Development and the extended scientific team to expand the bacterial vaccine pipeline.

Engage regularly with intellectual property attorneys to define and refine IP strategy for early-stage programs.

Build and foster effective relationships with senior leaders across Research, Biochemistry, Bioinformatics, Clinical and Translational Medicine, and Global Project Teams to ensure cross-functional alignment.

Ensure clear and objective communication of results, associated risks, uncertainties, and limitations across all projects and teams within the function.

Define training and development opportunities for junior colleagues in line with best practices and scientific principles.

Qualifications

PhD in microbiology, immunology, molecular biology, biochemistry, or a related discipline, with 8+ years of industry experience.

Proven leadership experience managing a team of junior scientists (PhD and non-PhD level).

Strong track record in bacterial vaccine research and/or bacterial pathogenesis.

Demonstrated experience leading efforts to characterize immune responses and protective efficacy of vaccine antigens in small animal disease models.

Familiarity with functional immunological assays, such as opsonophagocytic killing assays and serum bactericidal assays, used to measure vaccine-elicited immune responses.

Cross-functional collaboration experience, successfully delivering research and development programs in a biotech or pharmaceutical setting.

Experience supporting or leading interdisciplinary vaccine discovery or development programs from early research through candidate selection.

Proven ability to develop and manage budgets for research programs and external partnerships.

Excellent communication skills, both written and verbal, with strong business analysis and consultancy capabilities.

The annual base pay for this position ranges from $ 172,466.40 - $258,699.60. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

11-Aug-2026

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Job details

Seniority
Director
Function
Drug Discovery & Preclinical Research
Therapeutic area
Vaccines & Infectious Disease
Location
Gaithersburg, Maryland, United States of America
Employment type
Full time

How this role compares

Computed from every other active Drug Discovery & Preclinical Research role in our database, not just this employer's listings.

We currently track 94 comparable Director Drug Discovery & Preclinical Research roles across 23 biopharma companies.

94Comparable roles tracked
90Currently active
23Companies hiring similar roles
8Countries represented

Salary context

41 of 94 peers report a salary range (USD, annualized)

Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.

This roleSubject Not listed on this posting
Peer group range $129,125 – $322,650 (median $224,445)

Where these roles are based

Top locations among the 94 comparable roles

United States82
China3
India2
China's Mainland2
United Kingdom2
Spain1

+ 2 more countries

Seniority mix

94 of 94 peers have a known seniority level

Principal57
Director25
Senior Director12

Therapeutic area mix

21 of 94 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden

Oncology11
Immunology4
Cardiovascular / CVRM4
Neuroscience1
Respiratory1

Similar opportunities

The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.

60%similar
Lilly San Francisco, California, United States of America Director
Same function Same seniority Same country
60%similar
Lilly Indianapolis, Indiana, United States of America Director
Same function Same seniority Same country
60%similar
Lilly Indianapolis, Indiana, United States of America Director
Same function Same seniority Same country
60%similar
Lilly Louisville, Colorado, United States of America Director
Same function Same seniority Same country
60%similar
Gilead Sciences, Inc. Foster City, United States Director
Same function Same seniority Same country
60%similar
Gilead Sciences, Inc. Foster City, United States Director
Same function Same seniority Same country

How we calculate "similar"

No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.

Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.

60%
Director / Sr / Exec Dir - Applied Intelligence for Discovery (AI4D)
Lilly · San Francisco, California, United States of America · Director
Function Therapeutic area Seniority Country
60%
Director, Medicinal Chemistry
Lilly · Louisville, Colorado, United States of America · Director
Function Therapeutic area Seniority Country
60%
Director, Research Systems
Gilead Sciences, Inc. · Foster City, United States · Director
Function Therapeutic area Seniority Country
60%
Director, Statistical Genetics
Cambridge Discovery Hub · Cambridge Crossing, United States · Director
Function Therapeutic area Seniority Country
Unmatched or unknown dimensions score exactly the same: 0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.