Senior Manager (Upstream), MSAT
About this opportunity
Manufacturing Sciences, Analytics and Technology (MSAT) drives the industrialization and continuous improvement of biological processes and products. The function adopts new technologies and digital innovations while serving as the custodian of manufacturing process knowledge.
Positioned at the intersection of R&D and manufacturing, MSAT is a multidisciplinary function providing expertise in process sciences, manufacturing, process modelling, statistical analysis, validation, and technology transfer.
The Senior Manager, Upstream MSAT (Modulus Singapore) holds decision-making authority across key areas including talent management, team development, and budget allocation. From a technical perspective, the role is accountable for upstream process platforms and material-related decisions across process transfer, validation, manufacturing support, and investigations.
This role also drives innovation through the implementation of new technologies and materials, while ensuring process robustness, optimization, and continuous platform improvement.
Key Responsibilities
1. Team Leadership & Development
Build, lead, and develop a high-performing team of MSAT upstream scientists and engineers.
Define team structure, workflows, and deliverables to support process transfer and manufacturing operations.
Coach and develop team members, fostering a culture of accountability, continuous improvement, and open communication.
Drive employee engagement and enhance the organization’s attractiveness for talent in Singapore’s manufacturing sciences landscape.
2. Process Transfer & Project Leadership
Develop upstream process and engineering strategies to ensure consistency across products and platforms.
Establish systems and tools for standardization and knowledge management.
Lead site- or team-level programs/projects, including:
Defining manufacturing processes
Establishing validation and control strategies
Authoring complex technical documents and regulatory inputs
Ensure delivery of projects on time, within budget, and to quality standards.
3. Manufacturing Support
Organize MSAT upstream support to meet manufacturing needs, including after-hours on-call support.
Provide scientific expertise for routine operations and troubleshooting.
Lead complex investigations, assessments, and CAPA activities.
Ensure upstream process robustness for assigned products.
Drive Continued Process Verification (CPV) activities.
4. Lifecycle Management & Innovation
Act as the primary site contact for assigned products, ensuring alignment with global technical teams.
Lead initiatives for process and program improvements, including yield optimization and new technology implementation.
Serve as a subject matter expert and potentially a network-level key opinion leader.
Requirements
Core Competencies
Strong leadership with strategic vision and operational mindset.
Effective communicator in cross-functional and multicultural environments.
Excellent analytical and problem-solving capabilities with a data-driven approach.
Self-directed with the ability to work autonomously and drive initiatives.
Scientifically curious with a continuous improvement mindset.
Technical & Educational Background
Degree (or higher) in Biotechnology, Biological Sciences, Chemical Engineering, or related field.
Extensive industry experience in mammalian biopharmaceutical processes, including:
Process engineering
Technology transfer
Process validation
Manufacturing support
Strong understanding of upstream processes and parameter interactions.
Hands-on experience in pilot-scale or large-scale manufacturing environments (cell culture and/or purification).
Solid knowledge of cGMP requirements and current regulatory expectations.
Pursue progress , discover extraordinary
Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.
At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.
Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com !
Job details
How this role compares
Computed from every other active Manufacturing & CMC role in our database, not just this employer's listings.
We currently track 276 comparable Manager Manufacturing & CMC roles across 50 biopharma companies.
Salary context
95 of 276 peers report a salary range (USD, annualized)
Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.
Where these roles are based
Top locations among the 276 comparable roles
+ 17 more countries
Seniority mix
276 of 276 peers have a known seniority level
Therapeutic area mix
0 of 276 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden
No peers with a known therapeutic area yet.
Similar opportunities
The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.
How we calculate "similar"
No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.
Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.
0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.