Senior Group Director Scientist, Haematology R&D

The Senior Group Director Scientist fulfills the role of line manager to a number of clinical scientists within Hematology R and D. The role will have a major responsibility to mentor/develop/line manage junior clinical scientist within Hematology. The role holder may be required to serve as a member of the departmental leadership team, coordinate resource tracking and lead improvement initiatives in service of non-drug scorecard objectives.

You will also fulfill the role of a Senior Clinical Scientist assigned to Hematology and in that capacity you are an important part of the Project Team, working collaboratively with the program and study level physician or clinical lead as the expert in medical scientific aspects of the compound and its development. The accountabilities are broad however, the core accountabilities are the medical & scientific support for the development and implementation of early phase AstraZeneca sponsored clinical program strategy, externally sponsored collaborative research program strategy and studies, including clinical science support for initiating clinical trial(s), protocol/amendment development, IB/DSUR submissions, clinical trial documents, supporting clinical data review, interpretation of the study results and providing/supporting final recommendations to senior management.

You will drive and provide expert input to other non-assigned programmes, process improvement initiatives, development of junior clinical scientist within Hematology and provides strategic contributions to the global clinical scientist team.

As a key leadership member of the Global Project Team, this position demands strong collaborative communication skills, including the ability to engage with and influence a diverse range of business partners both within and external to AstraZeneca.

Will be required to line manage other Clinical Scientists including project allocations/resource management, recruitment & selection, personal development and performance management

May be required to serve as the Skills Lead for the Clinical Science group thereby being responsible for ensuring appropriate procedures, training and personal development approaches are in place for the skill group and best practice is identified and implemented

Contributes to the Departmental Leadership Team to ensure effective ways of working, identification and resolution of issues, departmental objective setting and may extend to resource allocation and tracking at the departmental level

Will lead or contribute to continuous improvement initiatives

May be required to manage key alliances (provider and academic)

As required you may be asked to act as Clinical Lead for the program/study or support the clinical lead

Leads or supports clinical input to the clinical development plan at all stages of the programme.

Leads or co-lead (with Translational and Bioscience Leads) the science-to-man sub team (TSST) to integrate the biology, translational and clinical science into the programme strategy

Leads/supports development of recommendation(s) on further development strategies to internal committees.

Leads (or supports, as required) the preparation of clinical and other data for governance and other presentations

Provide scientific/medical guidance to the study team, including the CRO team.

Leads the collaboration with the research scientists and translational scientists to provide clinical input to the development and review of data to support development of the pre-CDID compounds

Follows important developments and trends in the medical & scientific literature and disseminates updates to the project team and beyond ensuring all involved parties are aware of key developments and the impact on the strategy

Leads the development and review of content and quality of publications and inputs to development of the publication strategy

Where required leads project specific reviews of the competitor landscape to inform the program strategy

As required, the Group Director Clinical Scientist may be asked to act as Clinical Lead for the AZ sponsored study

Guides aspects of the Clinical Development Plan (CDP) and Clinical Study Protocols in keeping with the approved CDP and ensuring linkage of trial data to target product profile

Attends (in person or by TC) the Site Initiation Visits, to present the study design and key aspects of the protocol

Leads, (or supports as required), clinical data review and interpretation of the study and program level with input from the study or program Physician/Clinical Lead

Leads the compilation and interpretation of the data for and from the dose escalation committee/safety review committee, in collaboration with the program physician

Leads, approves or provides input for the protocols, amendments, Investigator Brochure, DSURs and other relevant strategic documents. Acts as lead clinical reviewer for Clinical Study Reports

Develops and builds investigator and site relationships to support site selection and study start up activities

Leads the development and implementation of the externally sponsored collaborative research (ESCR) strategy for a programme. The clinical scientist is the link between the project team and all external clinical research for the programme. For preclinical external research proposals, co-leads with the Bioscience Lead.

Leads investigator/site relationships for ESCR clinical proposal reviews, protocol review and approval, scientific oversight and discussions for academic basket/umbrella and ESCR studies

Represents the project internally and supports oncology drug development externally as a medical scientific expert with key external collaborators. Supports development of alliances as appropriate.

Support due diligence activities for potential in-licensing or collaborative opportunities and provides recommendations to senior management

Represents AstraZeneca as a support for external meetings such as advisory boards and

Identifies and manages risks within the ESCR portfolio, raises quality issues through the appropriate channels, maintains communications with key AstraZeneca stakeholders as required.

Drives key strategic initiatives within and beyond the Early Clinical Oncology group

Develops, coaches, mentors, motivates and inspires individuals within the organisation

Operates in compliance with GCP and relevant regulatory guidelines.

Minimum Qualifications:  

Advanced degree: PhD or PharmD with 12+ years of relevant industry experience and a proven track record in clinical development

Why AstraZeneca?

At AstraZeneca we are dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There is no better place to make a difference to medicine, patients, and society. We champion an inclusive culture that celebrates diversity and collaboration, and we are always committed to lifelong learning, growth, and development.

What’s Next?

Are you ready to bring transformative science to B-cell leukemia patients? We’d love to hear from you.

Date Posted

11-Aug-2026

Closing Date

25-Aug-2026

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.