Postdoctoral Fellow-Discovery Proteomics
About this opportunity
Career Category
Postdoctoral
Job Description
What you will do
Let’s do this! Let’s change the world.
The Post Doctoral Fellow at Amgen conducts research under the supervision of a mentor. They contribute to the design and execution of research projects, the analysis of data, and the preparation of scientific manuscripts.
Position Overview
This postdoctoral project focuses on understanding how biochemical state, cellular context, and subcellular localization influence substrate recruitment to E3 ligases such as Cereblon (CRBN). The fellow will leverage cutting-edge in-cell proximity labeling technologies (TurboID), quantitative proteomics, and cellular perturbation approaches to define mechanistically meaningful recruitment events relevant to molecular glue discovery.
The position is ideal for candidates with strong training in cell biology, molecular biology, or biochemistry, particularly in ubiquitin biology, targeted protein degradation, or E3 ligase biology, who are interested in applying proteomics approaches to mechanistic questions in targeted protein degradation.
Prior hands-on proteomics expertise is not required; however, familiarity with proteomics approaches and enthusiasm for learning advanced quantitative proteomics methodologies are highly desirable.
Key Responsibilities
Design and execute cellular and biochemical experiments to study molecular glue–mediated E3 ligase recruitment
Develop and apply proximity labeling and targeted perturbation strategies in engineered cellular systems
Investigate context-dependent recruitment mechanisms involving post-translational modifications, protein complexes, and subcellular localization
Collaborate closely with proteomics scientists to generate and interpret quantitative mass spectrometry datasets
Integrate biological and proteomic datasets to develop mechanistic models of induced proximity biology
Present findings and contribute to the preparation of scientific manuscripts, publications, and scientific communications.
Basic Qualifications
PhD completed prior to start date in Cell Biology, Molecular Biology, Biochemistry, Chemical Biology, Immunology, Cancer Biology, or related discipline
Preferred Qualifications
Strong background in cell and molecular biology with demonstrated experimental independence
Experience in ubiquitin biology, E3 ligases, targeted protein degradation, or induced proximity biology
Experience with mammalian cell culture, CRISPR engineering, protein interaction studies, or signaling biology
Familiarity with proteomics or mass spectrometry-based approaches
Strong publication record, including first-author publications in high-impact peer-reviewed journals
Strong communication and collaborative skills
Scientific Environment
The fellow will join a highly collaborative environment at the intersection of proteomics, TPD biology, and translational drug discovery. The project leverages established high-throughput TurboID proximity labeling workflows, advanced quantitative proteomics platforms, and close collaborations across discovery biology and proteomics teams.
This position offers outstanding opportunities for scientific growth in induced proximity biology, quantitative proteomics, and translational therapeutic discovery, with expected authorship on high-impact publications.
Apply now and make a lasting impact with the Amgen team.
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Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Sponsorship
Sponsorship for this role is not guaranteed.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
. Salary Range
81,178.40USD -109,829.60 USD
Job details
How this role compares
Computed from every other active Drug Discovery & Preclinical Research role in our database, not just this employer's listings.
We currently track 56 comparable Intern/Fellow/Postdoc Drug Discovery & Preclinical Research roles across 17 biopharma companies.
Salary context
18 of 56 peers report a salary range (USD, annualized)
Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.
Where these roles are based
Top locations among the 56 comparable roles
Seniority mix
56 of 56 peers have a known seniority level
Therapeutic area mix
9 of 56 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden
Similar opportunities
The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.
How we calculate "similar"
No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.
Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.
0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.