AstraZeneca Posted August 12, 2026

Facilities Maintenance Supervisor

Tarzana, California, United States of America Full time
Manufacturing & CMC

AstraZeneca is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.

About this opportunity

Position Summary:

The Facilities Maintenance Supervisor leads maintenance operations to ensure the safe, compliant, and highly reliable performance of critical manufacturing and facility systems supporting cell therapy production in Tarzana, CA. In a Cell Therapy environment, where products are often patient-specific and time-sensitive, this role is critical to maintaining uninterrupted operations, cleanroom conditions, and strict chain-of-identity and chain-of-custody controls Tarzana, CA. The role integrates reliability engineering principles with daily maintenance execution, focusing on eliminating repeat failures, reducing unplanned downtime, and improving asset lifecycle performance in a highly regulated environment governed by FDA expectations and advanced therapies guidelines.

Success in this role requires the ability to:• Lead teams in a fast paced, patient-centric manufacturing environment• Balance speed, compliance, and precision• Anticipate and mitigate risks to critical, often irreplaceable batches• Drive transition from reactive to predictive maintenance strategies• Collaborate multi-functionally with Manufacturing, Quality, and Engineering to support 7 days cell therapy operations

Ultimately, the Maintenance Supervisor plays a direct role in ensuring that life-saving therapies reach patients safely, reliably, and on time, by maintaining the integrity and performance of the systems that produce them.

Responsibilities:

Leadership & Team Management: Manage and mentor maintenance technicians; set clear expectations for safety, quality, and performance; lead daily tier meetings and shift handovers; build a culture of ownership, urgency, and continuous improvement; collaborate with Engineering, Quality, and Operations.

Maintenance Execution & Compliance: Ensure all activities meet GMP, FDA, and site standards; review and approve complete, accurate work orders; enforce CMMS usage (e.g., SAP); lead aspects of preventive and corrective maintenance and calibrations; maintain inspection readiness and support audits.

Reliability & Asset Management: Implement reliability‑centered maintenance; investigate failures using RCA and FMEA; improve MTBF and MTTR; identify and resolve “bad actor” equipment; partner on upgrades and lifecycle management.

Planning & Scheduling: Work with the Maintenance Planner to prioritize and schedule work; secure parts, tools, and permits in advance; validate and refine job plans; increase labor efficiency and minimize reactive work.

Safety, Health, and Environment (SHE): Enforce LOTO, confined space, and permit systems; conduct safety observations, audits, and incident investigations; lead by example to sustain a zero‑incident culture.

Continuous Improvement: Remove waste from maintenance processes; increase schedule compliance, PM efficiency, and spare‑parts management performance; lead or participate in Kaizen and Lean initiatives.

Work Environment: AZ is a cGMP regulated pharmaceutical manufacturing facility. We require your presence on the production floor and occasional off-shift support This may involve gowning for cleanroom environments

Minimum requirements:

High school diploma/GED required.8+ years in industrial facilities maintenance/leadership experience

4+ years of leadership experience in a pharmaceutical, biotech, or GMP regulated environment (medical device/food service may be acceptable.)

Desirable:

Technical diploma/apprenticeship in HVAC or Boiler maintenance.

Bachelor’s degree in Mechanical engineering or Facilities Management is a plus.

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The annual base salary for this position ranges from $89,874 to $134,812. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles).

Our Benefits:

Benefits offered include:

A qualified retirement program [401(k) plan]

Paid vacation, holidays, and paid leaves

Health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment.

#celltherapy

Date Posted

12-Aug-2026

Closing Date

25-Aug-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Job details

Seniority
Not listed
Function
Manufacturing & CMC
Therapeutic area
Not listed
Location
Tarzana, California, United States of America
Employment type
Full time

How this role compares

Computed from every other active Manufacturing & CMC role in our database, not just this employer's listings.

We currently track 1527 comparable Manufacturing & CMC roles across 125 biopharma companies.

1527Comparable roles tracked
1435Currently active
125Companies hiring similar roles
44Countries represented

Salary context

455 of 1527 peers report a salary range (USD, annualized)

Peers share this role's job function. This posting doesn't list a seniority level, so peers aren't narrowed by seniority either -- the range below may span more levels than usual.

This roleSubject $89,874/yr – $134,812/yr
Lowest disclosed · Senior Scientist II – CMC Developmental Sciences · AbbVie $0/hr – $0/hr (≈ $0–$0/yr)
Peer group range $0 – $540,400 (median $140,000)

Where these roles are based

Top locations among the 1527 comparable roles

United States781
India104
Germany74
Singapore67
France64
Ireland54

+ 38 more countries

Seniority mix

705 of 1527 peers have a known seniority level

Senior251
Manager165
Principal79
Associate68
Director64
Associate Director44
Senior Director21
Intern/Fellow/Postdoc8
Executive/VP5

Therapeutic area mix

7 of 1527 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden

Vaccines & Infectious Disease6
Oncology1

Similar opportunities

The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.

40%similar
Alexion New Haven, Connecticut, United States of America
Same function Same country
40%similar
AstraZeneca Cambridge, Massachusetts, United States of America Director
Same function Same country
40%similar
Alexion New Haven, Connecticut, United States of America
Same function Same country
40%similar
40%similar
Lilly Boston, Massachusetts, United States of America Associate
Same function Same country
40%similar
Lilly Indianapolis, Indiana, United States of America Senior Director
Same function Same country

How we calculate "similar"

No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.

Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.

40%
Scientist II, LC Development, Biologics Analytical Development
Alexion · New Haven, Connecticut, United States of America · Seniority not listed
Function Therapeutic area Seniority Country
40%
Director, Global Regulatory Affairs – Chemistry, Manufacturing and Controls (CMC), Platform Innovation – Synthetic Peptides and Oligonucleotides
Lilly · Indianapolis, Indiana, United States of America · Director
Function Therapeutic area Seniority Country
40%
Senior/Principal Scientist, Bioprocess Purification Development
Lilly · Indianapolis, Indiana, United States of America · Principal
Function Therapeutic area Seniority Country
40%
Senior Principal Scientist - Bioanalytical Research
Lilly · Louisville, Colorado, United States of America · Principal
Function Therapeutic area Seniority Country
Unmatched or unknown dimensions score exactly the same: 0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.