Associate Scientist - Therapeutic Proteins

Build our future together:

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a highly motivated, detail-oriented, and dependable Associate Scientist to join Therapeutic Proteins - Antibody Radioconjugates Technology, conjugating antibodies with bifunctional chelates and fluorescent probes, and radiolabeling conjugated antibodies to support preclinical immunoPET (iPET) and Cryo-fluorescence Tomography (CFT) imaging. You'll generate and characterize Zr-89 radiolabeled and fluorescently-conjugated tracers from our portfolio of antibodies and antibody-based therapeutics, enabling quantitative in vivo imaging studies across Oncology, Immuno-Oncology, and other therapeutic focus areas. Your work will directly enable same-day imaging studies that visualize biodistribution, tumor/tissue targeting, and pharmacokinetics of therapeutic candidates in preclinical models.

When & where:

Location: Tarrytown, NY - On-site

Discover your role:

Performs bioconjugation of antibodies with bifunctional chelating agents (DFO, DOTA, etc.) and fluorescent probes following validated protocols

Characterizes antibody bioconjugates using SE-HPLC, SDS-PAGE, Western blot, and UV/Vis spectroscopy

Radiolabels bioconjugated antibodies with Zr-89, Cu-64, or other radionuclide isotopes; purifies radiolabeled products for same-day use in time-critical imaging studies

Runs quality control testing using radio-HPLC, radio-iTLC, and gamma counting to verify tracer quality before release

Maintains mammalian cell culture lines and performs cell-based assays to validate tracer binding and function

Coordinates tracer preparation timelines with imaging scientists and project teams across multiple therapeutic areas

Maintains detailed electronic laboratory notebooks and radiation safety records in compliance with regulations

Maintains instruments, troubleshoots instrumental/experimental problems, and orders/maintains supplies

This job might be for you if you:

Have hands-on experience with protein chemistry, bioconjugation, and chromatographic techniques; experience performing radiochemistry is a plus

Thrive in a collaborative, fast-paced environment where reliability and punctuality directly impact team success

Take pride in maintaining accurate, complete laboratory records

Excel at attention to detail and following established protocols with precision

Are self-motivated and eager to work independently after training

Have strong communication skills

This role requires:

B.S. in Chemistry, Biochemistry, Chemical Engineering, Chemical Biology, or a related field with 1-2 years of laboratory experience

Comfort working with radioactive materials and willingness to complete radiation safety training

Hands-on experience with protein chemistry and bioconjugation techniques, or strong foundational knowledge with willingness to learn

Experience with chromatographic techniques (HPLC, FPLC, or column chromatography) and mammalian cell culture

Proficiency with computers, data analysis software (Excel, Prism, or similar), and electronic laboratory notebook systems

Ability to lift 50 lbs

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all  qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate.  The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.  Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/ . For other locations, additional information will be provided during the recruitment process.  If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)

$70,300.00 - $110,100.00